To address the vulnerability of traditional standing-seam metal roofing systems to wind-induced uplift failure under strong winds, this paper proposes a novel high-rib welded stainless steel roofing system. Full-scale 1∶1 model tests were carried out on two material configurations: Model 1, fabricated from 0.6 mm thick 445J2 ferritic stainless steel, and Model 2, fabricated from 0.7 mm thick 316L austenitic stainless steel. The test results demonstrated that Models 1 and 2 successfully withstood 5000 cycles of dynamic fluctuating pressure at 5.39 kPa and 8.0 kPa, respectively, with static ultimate bearing capacities reaching 11.2 kPa and 9.8 kPa, respectively. In addition, a finite element numerical model was established to analyze the influence of stiffening rib height on system performance. The computational results indicated that increasing the rib height significantly reduced panel deformation and the stress in the plate rib beneath the weld. When the rib height was increased from 1.5 mm to 5.0 mm, both deformation and stress decreased markedly; however, the difference between 3.0 mm and 5.0 mm tended to plateau. This study proves that the proposed roofing system exhibits excellent wind uplift resistance and holds significant potential for engineering applications.