The applications of performance-based design methods on eccentric web member steel truss structural system were discussed. Based on the mechanical properties of non-uniform beams, the study examineed the influence of the ratio of the stiffness between the middle section of the eccentric web member steel truss and the connecting beams at the both ends on the internal force distribution of the truss. Through rational preliminary design, the bending stiffness ratio between the middle part and connecting beams was controlled, which allowed the demands of connecting beams to be easily satisfied while simultaneously reducing the demands of components and connections within the relevant ranges of the main structure. The seismic performance, stress of joints, human comfort of floor vibration, and progressive collapse prevention of the eccentric web member steel truss corridor structure were designed and assessed respectively. The results demonstrated that, through rational performance-based design, each index satisfied the requirements of expected performance objectives. The research also could provide references for similar projects.