Abstract: With growing urbanization, long-span pedestrian bridges have become an integral part of modern urban infrastructure due to their unique structural forms and essential architectural functions. However, such bridges are prone to significant wind-induced vibrations under wind loads, potentially compromising structural safety and user comfort. The wind-induced vibration control for a long-span pedestrian bridge was investigated, and a wind-resistant design method based on comfort performance was proposed. Using the ribbon-like pedestrian bridge of the Suzhou Cultural Expo Center as a case study, wind load characteristic data for the bridge under various wind speeds and directions were obtained from wind tunnel experiments and nonlinear time-history analysis, and its dynamic responses were also systematically analyzed. A comfort-based wind-resistance performance design framework was established to improve the comfort of the pedestrian bridge by optimizing structural design and vibration reduction measures. The study employed multi-tuned mass damper (MTMD) technology to effectively control the first three-ordor vibration modes of the structure. The results indicated that the acceleration response of the structure was significantly reduced with the MTMD system in the field, achieving a vibration reduction efficiency exceeding 50%. Under large wind speeds, the peak accelerations in both vertical and lateral directions met the requirements of relevant standards.