The metal-faced sandwich panel has been used in the envelope structure for its advantages of thermal insulation, noise reduction, light weight and high assembly efficiency. Based on the structure of metal sandwich panels, a new type of profiled steel sheet and polyurethane sandwich slab(PSSPSS) was proposed. In order to study the flexural capacity of PSSPSS, two-point symmetric load static test was carried out on the slab. Based on the experimental results, the finite element analysis model of PSSPSS was proposed and verified, and the parameters of the channel steel slab thickness, profiled steel sheet thickness and polyurethane density were analyzed. The results show that:the failure mode of sandwich slab is mainly shown as too large deflection, the maximun deflection is one forty-second of the span of the slab, and the channel steel at the middle section of the span appears distortion buckling. After the sandwich slab is bent and deformed, the channel steel reaches the yield state first, while the material properties of the compression steel plate are not fully developed. Compared with traditional metal sandwich panels, the bearing capacity and stiffness of PSSPSS are improved by 203% and 203% respectively.The thickness of slab and profiled steel sheet has significant influence on the bearing capacity and stiffness of sandwich slab, while the thickness of slab has more obvious influence on stiffness than the thickness of profiled steel sheet. the thickness of slab increases from 120 mm to 160 mm, the bearing capacity of sandwich slab increases by 87% in normal use, 63% in ultimate bearing capacity and 88% in stiffness. the thickness of steel sheet increases from 1 mm to 3 mm, the bearing capacity of sandwich slab increases by 59% in normal use and 84% in ultimate bearing capacity, stiffness increased by 61%.The variation of polyurethane density has little influence on the bearing capacity and stiffness of sandwich slab. the density changes from 45 kg/m3 to 90 kg/m3, the bearing capacity of sandwich slab increases by 12% in normal use, only 2% in ultimate bearing capacity, and 12% in stiffness.