Abstract: In order to adapt to the rapid domestic and overseas development of structural steel and to meet the requirements of steel structure on the mechanical properties and special properties of steel plate for construction, Shougang has independently developed 460 MPa antiseismic and anti-corrosion fire-resistant steel(hereafter referred to as 460FRW). In this paper, the 460FRW steel plates of different specifications developed by Shougang are taken as samples for tensile and impact tests. The experimental data are statistically analyzed to research on the yield strength,the partial coefficient of resistance and the design strength value of 460FRW steel, so as to provide the recommended design strength value for the 460FRW anti-seismic and anti-corrosion fire-resistant steel produced by Shougang in engineering design. The 460 FRW steel plate used in the test is provided by Shougang, and the thickness specifications are 10, 14, 20, 28 mm, respectively. According to the strength grade of the steel plate and the section size of the specimen, the yield load of the specimen is between 30% and 60% of the nominal tensile force of the testing machine, which is within the reasonable range of the influence of the flexibility of the testing machine. The testing machine is automatically controlled by computer, which can automatically identify and output the upper and lower yield strength and tensile strength for material uncertainty analysis. The experimental data of yield strength of 460FRW steel are obtained by experiments. Based on the test data, the uncertain statistical parameters of material properties, geometric characteristics and calculation mode of steel plate are further calculated and determined. By synthesizing these three uncertain statistical parameters, the resistance uncertain statistical parameters of 460FRW steel are calculated. Combined with the statistical parameters of load uncertainty, the resistance partial coefficients of 460FRW steel typical members under four load ratios, axial tension, axial compression, eccentric compression (bending moment acting in plane), eccentric compression (bending moment acting out of plane) and steel beam (elastic and plastic failure) are calculated. Through the analysis, when the load ratio ρ = 2. 00, the partial coefficient of elastic failure resistance of steel beam is the highest, which can be used as the statistical analysis value of partial coefficient of resistance of 460FRW steel.