Abstract: In recent years, although China's highway steel structure bridge construction has made great achievements, but as a result of steel bridge professional characteristics of strong, high technology, combined with the collaborative design and manufacturing unit is poorer, designers often ignore the technology of steel bridge manufacture, so in the process of steel bridge manufacture, presents the design and manufacture of the disconnect between phenomenon, in order to improve design staff awareness of steel bridge structure detail processing, combining with our country more than combination bridge of steel bridge construction details for more detailed instructions. The disjunction between the design and manufacturing of steel bridge is mainly reflected in: 1) Some steel plates or sections cannot be purchased due to the influence of rolling capacity, market supply and supply quantity of the steel mill; 2) In the design of steel bridge, the thickness of webs or cover plates in the manufacturing segment should be unified to reduce the waste of manufacturing resources; 3) The composite beam members should be welded in the factory, and the installation segment interface should be connected by high-strength bolts. In the structural design, the screw space of bolts and the bridge installation relationship should be considered. In order to prevent the occurrence of slurry leakage, the thickness of the rubber strip should not be too small; The transverse slope design is realized by adjusting the height of the longitudinal beam. The upper cover plate can be set in a horizontal state, and the transverse slope changes can be realized through the compressibility of the rubber strip. 4)The composite beam steel plate beam manufacturing alignment should be "dead load +1/2 live load" reverse arch superposition bridge longitudinal slope generated vertical alignment, and should consider the impact of erection construction conditions on the bridge alignment; In order to realize the standardized manufacturing, the curve vector height of steel plate beam manufacturing segment is small, so it is appropriate to adopt the scheme of "replacing the curve with the straight curve". The precision relationship between steel structure members and concrete prefabricated parts should be considered in the design of composite beam anti-collision guardrail. 5)The steel bridge should be reasonably set up welding joints according to the need to minimize the damage caused by excessive welding, for the partial penetration fillet weld with penetration requirements should make clear requirements. 6)The weathering steel bridge design needs to pay attention to the details of the bridge deck waterproof, beam body ventilation, support protection and so on, at the same time according to the environment of the bridge to determine the coating or coating free use. 7)The conventional span bridge has the characteristics of long line and complex linear shape, so the design mode of "general drawing + special drawing" can be adopted. In order to ensure the accuracy of bridge linear shape and connection relation of components in the transformation process of construction detail drawing, it is crucial to select a reasonable detail drawing transformation mode. The detail treatment of steel structure bridge described in this paper has a strong guiding significance for improving the disjunction between the design and manufacture of steel structure bridge and enhancing the level of detail treatment of steel structure bridge designers in China, and also provides reference for the design and manufacture of similar steel structure bridge.